About Us

The Advanced Biomedical Computational Science (ABCS) is a part of the Information Systems Program at SAIC-Frederick, Frederick National Laboratory for Cancer Research (FNLCR). The ABCS provides technology development, scientific consultation, collaboration and training, and high-performance computing support to the National Cancer Institute (NCI) and National Institutes of Health (NIH) scientists and staff.

Below is a list of a few selected publications relevant to non-B DB by the ABCS personnel:

Author(s) Title and Journal Link
Cer RZ, Bruce KH, Donohue DE, Temiz NA, Mudunuri US, Yi M, Volfovsky N, Bacolla A, Luke BT, Collins JR, Stephens RM. Searching for non-B DNA-forming motifs using nBMST (non-B DNA motif search tool. Curr Protoc Hum Genet. 2012 Apr;Chapter 18:Unit 18.7.1-22. Pubmed
Bacolla A, Wang G, Jain A, Chuzhanova NA, Cer RZ, Collins JR, Cooper DN, Bohr VA, Vasquez KM. Non-B DNA-forming sequences and WRN deficiency independently increase the frequency of base substitution in human cells. J Biol Chem. 2011 Feb. Pubmed
Cer RZ, Bruce KH, Mudunuri US, Yi M, Volfovsky N, Luke BT, Bacolla A, Collins JR, Stephens RM Non-B DB: a database of predicted non-B DNA-forming motifs in mammalian genomes. Nucleic Acids Res. 2011;39(Database issue):D383-91. Pubmed
Akagi K, Stephens RM, Li J, Evdokimov E, Kuehn MR, Volfovsky N, Symer DE MouseIndelDB: a database integrating genomic indel polymorphisms that distinguish mouse strains. Nucleic Acids Res. 2010;38(Database issue):D600-6. Pubmed
Mudunuri U, Che A, Yi M, Stephens RM. bioDBnet: the biological database network. Bioinformatics. 2009;25(4):555-6. Pubmed
Mechanic LE, Luke BT, Goodman JE, Chanock SJ, Harris CC. Polymorphism Interaction Analysis (PIA): a method for investigating complex gene-gene interactions. BMC Bioinformatics 2008;9:146. Pubmed
Bacolla A, Larson JE, Collins JR, Li J, Milosavljevic A, Stenson PD, Cooper DN, Wells RD. Abundance and length of simple repeats in vertebrate genomes are determined by their structural properties. Genome Res. 2008 Oct;18(10):1545-5. Pubmed
Bacolla A, Collins JR, Gold B, Chuzhanova N, Yi M, Stephens RM, Stefanov S, Olsh A, Jakupciak JP, Dean M, Lempicki RA, Cooper DN, Wells RD. Long homopurine*homopyrimidine sequences are characteristic of genes expressed in brain and the pseudoautosomal region. Nucleic Acids Res. 2006 May 19;34(9):2663-75. Pubmed
Goodman JE, Mechanic LE, Luke BT, Ambs S, Chanock S, Harris CC. Exploring SNP-SNP interactions and colon cancer risk using Polymorphism Interaction Analysis. Intl. J. Cancer 2006;118:1790-7. Pubmed